Definition of Pseudomelanosis coli

Pseudomelanosis coli (Melanosis coli): A benign, reversible condition usually, but not always, associated with long-term use of anthranoid laxatives in which pigment deposition in the lamina propria of the large intestine results in a brown to black discoloration of the mucosa (lining) of the large intestine. Melanosis coli produces no symptoms and is indicative of chronic laxative use.