Definition of Y-linked inheritance

Y-linked inheritance: Inheritance of genes on the Y chromosome. Since only males normally have a Y chromosome, Y-linked genes can only be transmitted from father to son.

Y-linked inheritance is also called holandric inheritance.

It has often been said that little is known about Y-linked inheritance. This is no longer true. As of the year 2000, a number of genes were known to be Y-linked including:

ASMTY (which stands for acetylserotonin methyltransferase), TSPY (testis-specific protein), IL3RAY (interleukin-3 receptor), SRY (sex-determining region), TDF (testis determining factor), ZFY (zinc finger protein), PRKY (protein kinase, Y-linked), AMGL (amelogenin), CSF2RY (granulocyte-macrophage colony-stimulating factor receptor, alpha subunit on the Y chromosome), ANT3Y (adenine nucleotide translocator-3 on the Y), AZF2 (azoospermia factor 2), BPY2 (basic protein on the Y chromosome), AZF1 (azoospermia factor 1), DAZ (deleted in azoospermia), RBM1 (RNA binding motif protein, Y chromosome, family 1, member A1), RBM2 (RNA binding motif protein 2) and UTY (ubiquitously transcribed TPR gene on Y chromosome).

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